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目的：观察不同浓度和ｐＨ利多卡因对蛙离体坐骨神经复合动作电位的影响。方法：用５％碳酸氢钠调制出７种不同浓度和ｐＨ值的利多卡因溶液进行离体蛙坐骨神经标本实验，测定动作、电位衰减时间。结果和结论：将盐酸利多卡因溶液ｐＨ由４．５增加到６．０，可明显缩短其起效时间，增强神经阻滞作用，但对作用持续时间无明显影响。
Objective: To observe the effects of different concentrations and pH values of lidocaine on the combined action potentials of sciatic nerve in frogs. Methods: Seven kinds of lidocaine nerve specimens were prepared from 5 different concentrations and pH values of 5% sodium bicarbonate solution. The action and potential decay time were measured. RESULTS AND CONCLUSION: Increasing the pH value of lidocaine hydrochloride solution from 4.5 to 6.0 significantly shortened the onset time and enhanced the nerve block, but had no effect on the duration of action.