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中药尤其是复方的作用机理研究迄今为止都比较困难,方法亦不多,本文应用细胞培养和血清药理方法对菌开蒿汤的保肝机理进行了研究,以探讨该方法在中药复方作用机理研究中应用的可行性。茵陈蒿汤出自《伤寒论》,是治疗湿热黄疸的要方,临床用于多种黄疸症及传染性肝炎、急性病毒性肝炎、重型肝炎的治疗。本文研究了茵陈蒿汤醇提物对小鼠巨噬细胞释放TNF的影响,探讨其保肝作用与TNF的关系。
The study on the mechanism of action of traditional Chinese medicine, especially compound, has been difficult so far, and there are not many methods. This article applied cell culture and serum pharmacological methods to study the hepatoprotective mechanism of Jikaizhi decoction to explore the mechanism of this method in traditional Chinese medicine compound. Application feasibility. Yin Chen Hao Tang from the “Treatise on Febrile Diseases,” is a prescription for the treatment of hot and humid jaundice, clinical for a variety of jaundice and infectious hepatitis, acute viral hepatitis, severe hepatitis treatment. In this paper, the effect of alcohol extracts from Yinchenhao decoction on the release of TNF from mouse macrophages was studied, and the relationship between hepatoprotective effect and TNF was explored.