论文部分内容阅读
目的 :为了比较不同给药方式对Graves’病的疗效。方法 :将 2 0例患有Graves’病的患者按治疗方式分为外敷组、口服组、手术组 3组〔前两组术前均以他巴唑 (MMI ,4 0mg/d)和氢化可的松 (HC ,4 0mg/d)治疗 7天以上〕。以HPLC比较了 3组患者甲状腺、血清中MMI及HC的含量。结果 :外敷组甲状腺中MMI及HC浓度均高于口服组 ,分别是后者的 1.17和 2 .64倍 ;外敷组血清中MMI及HC浓度均明显低于口服组。对 3组患者的疗效及副作用也同时进行了比较 ,结果外敷组的疗效明显高于口服组 ,且副作用较小。结论 :外敷法给药是一种理想的治疗Graves’病的方式
Objective: To compare the efficacy of different modes of administration on Graves’ disease. Methods: Twenty patients with Graves’ disease were divided into external application group, oral group and operation group according to the way of treatment. The three groups were treated with methimazole (MMI, 40mg / d) and hydrogenation Of loose (HC, 40mg / d) for more than 7 days]. Thyroid, serum MMI and HC contents in the three groups were compared by HPLC. Results: The concentrations of MMI and HC in the thyroid gland were significantly higher than those in the oral group (1.17 and 2.64 folds, respectively). The serum concentrations of MMI and HC in the external application group were significantly lower than those in the oral group. The efficacy and side effects of the three groups of patients were also compared at the same time, the results of external application group was significantly higher than the oral group, and the side effects of smaller. Conclusion: Topical administration is an ideal way to treat Graves’ disease