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采用限制性酶切片段长度多态性分析法，检测在胃癌高发区庄河检出的１９例胃癌高系家族成员胃蛋白酶原Ｃ基因多态性，发现三种常见片段及一种稀有片段。对其中４例携带稀有片段的受检者进行了胃镜追踪观察，２．５年后发现１例早期胃癌。本文对此作了初步探讨。
The pepsinogen C gene polymorphisms in 19 high gastric cancer family members detected in Zhuanghe, a high-risk area of gastric cancer, were detected by restriction fragment length polymorphism analysis. Three common fragments and one rare fragment were found. Four of the subjects who carried rare specimens underwent gastroscopy, and one case of early gastric cancer was discovered 2.5 years later. This article made a preliminary discussion on this.