新型辅料羟丙基甲基纤维素(HPMC),不仅具有粘合与崩解的两重性质,还有较好的成膜性。本文把HPMC参入单淀粉浆中作为片子的粘合剂,参照文献方法,通过以往实验得出的因素—辅料、水份、筛目进行正交设计。设计几种配方法进行小试,通过质量检查、破坏性试验和扩大试验筛选得到一种较好的配方,对提高维生素C片的质量有一定的实用价值。羟丙基甲基纤维素(HPMC)为无毒、无味,白色的纤维素状的疏松体,溶于冷水而 New excipient hydroxypropyl methylcellulose (HPMC), not only has the dual nature of adhesion and disintegration, but also better film-forming. In this paper, HPMC into single starch slurry as a binder of the film, with reference to the literature method, through the experimental results of the factors - accessories, water, sieve mesh for orthogonal design. Design several methods for small test, through the quality inspection, destructive testing and screening to get a better screening formula, to improve the quality of vitamin C tablets have some practical value. Hydroxypropyl methylcellulose (HPMC) is a non-toxic, tasteless, white cellulosic form that is soluble in cold water while