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利用手性镧系位移试剂Ｅｕ（ＴＦＣ）３的作用，测定萘普生甲酯化衍生物的１ＨＮＭＲ谱来确定萘普生对映体相对含量。在样品浓度为０．１７ｍｏｌ／Ｌ，位移试剂和被测样品摩尔比为０．３１８附近时，定量信号峰ＣＯＯＣＨ３的对映体化学位移差值Δ（Δδ）为５．４Ｈｚ。平均回收率１００．８％，ＲＳＤ为１．３１％（ｎ＝４）。
Using the chiral lanthanide shift reagent Eu (TFC) 3, the naproxen methyl ester derivatives 1H-NMR spectra were determined to determine the relative content of naproxen enantiomers. When the sample concentration is 0.17mol / L and the molar ratio of the displacement reagent to the sample to be tested is around 0.318, the difference Δ (Δδ) of the chemical shift of the quantitation signal peak COOCH3 is 5.4Hz. The average recovery was 100.8% with a RSD of 1.31% (n = 4).