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目的分析甲状腺功能异常与脑出血急性期出血部位的相关性。方法收集2012年3月-2014年5月该院神经内科就诊的急性脑出血患者220例,其中丘脑出血患者57例,非丘脑出血患者163例。分别检测所有患者甲状腺激素水平,并统计各组甲状腺功能异常患者数,计算甲状腺功能异常与脑出血部位的相关性。结果脑出血患者初诊时FT3、FT4、TT3、TT4及TSH均相近,差异均无统计学意义(P>0.05)。出血24h检测,丘脑出血组血清FT3和TT3水平均低于非丘脑出血组,差异均有统计学意义(P<0.05)。而2组患者血清FT4、TT4及TSH水平相差不大,差异无统计学意义(P>0.05)。丘脑出血组甲状腺功能异常发生率为73.68%高于非丘脑出血组的34.97%,差异有统计学意义(P<0.05)。经相关系数检测比较,R值2.107,95%可信区间1.372~2.512,故存在显著相关性(P<0.05)。结论甲状腺功能异常与脑出血急性期出血部位存在相关性,丘脑出血患者更易出现甲状腺功能异常。
Objective To analyze the correlation between thyroid dysfunction and bleeding site in acute stage of cerebral hemorrhage. Methods A total of 220 patients with acute cerebral hemorrhage admitted from March 2012 to May 2014 in neurology department of the hospital were collected, including 57 patients with thalamic hemorrhage and 163 patients with non-thalamic hemorrhage. Thyroid hormone levels were detected in all patients, and the number of patients with thyroid dysfunction in each group statistics to calculate the correlation between thyroid dysfunction and cerebral hemorrhage sites. Results There was no significant difference in the FT3, FT4, TT3, TT4 and TSH levels between the two groups (P> 0.05). Hemorrhage 24h test, thalamic hemorrhage serum FT3 and TT3 levels were lower than non-thalamic group, the differences were statistically significant (P <0.05). There was no significant difference between the two groups in serum FT4, TT4 and TSH levels (P> 0.05). The incidence of thyroid dysfunction in thalamic hemorrhage group was 73.68% higher than that in non-thalamic group (34.97%), the difference was statistically significant (P <0.05). The correlation coefficient detection and comparison, R value 2.107, 95% confidence interval 1.372 ~ 2.512, so there is a significant correlation (P <0.05). Conclusions Thyroid dysfunction is related to the site of hemorrhage in acute stage of cerebral hemorrhage. Patients with thalamic hemorrhage are more likely to have thyroid dysfunction.