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目的探讨短肽型肠内营养剂在晚期早产儿疾病期营养支持中的效果。方法对2011年1月至2012年1月上海交通大学医学院附属新华医院新生儿病区收治的晚期早产儿进行临床观察研究,将其随机分为观察组(短肽型肠内营养剂组)及对照组(整蛋白型普通早产儿营养剂组),观察生长发育、喂养不耐受、营养学指标、感染性疾病及过敏性疾病发生率等。结果 (1)观察组与对照组在头围、身长、体重增长3方面差异均无统计学意义(P均>0.05)。(2)观察组达全肠道喂养时间比对照组明显缩短,观察组喂养不耐受发生率明显小于对照组(P均<0.05)。(3)于营养支持第7天观察组血视黄醇结合蛋白高于对照组,第14天观察组血视黄醇结合蛋白、前白蛋白、白蛋白均高于对照组(P均<0.05)。(4)营养支持3个月内,观察组感染性疾病与过敏性疾病发生率明显小于对照组(P均<0.05),在体格生长方面,两组差异则无统计学意义(P>0.05)。结论短肽型肠内营养制剂能明显减少晚期早产儿喂养不耐受的发生率,改善其疾病期营养状况,并能促进其免疫系统成熟,减少感染与过敏性疾病的发生率。
Objective To investigate the effect of short peptide enteral nutrition in nutritional support in the disease stage of advanced preterm infants. Methods From January 2011 to January 2012, clinical observation of advanced preterm infants admitted to Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine was conducted. The patients were randomly divided into observation group (short peptide enteral nutrition group) And control group (whole-protein normal preterm infant nutrition group), observe the growth and development, feeding intolerance, nutrition indicators, infectious diseases and the incidence of allergic diseases. Results (1) There was no significant difference in head circumference, body length and body weight between the observation group and the control group (P> 0.05). (2) The total intestine feeding time in the observation group was significantly shorter than that in the control group, and the incidence of feeding intolerance in the observation group was significantly less than that in the control group (all P <0.05). (3) On the 7th day of nutritional support, the serum retinol binding protein in observation group was higher than that in control group. On day 14, the serum retinol binding protein, prealbumin and albumin in observation group were higher than those in control group (all P <0.05 ). (4) Nutritional support Within 3 months, the incidence of infectious diseases and allergic diseases in the observation group was significantly less than that of the control group (all P <0.05). There was no significant difference in physical growth between the two groups (P> 0.05) . Conclusion Short peptide enteral nutrition can significantly reduce the incidence of feeding intolerance in advanced preterm infants, improve their nutritional status in the disease period, and promote their immune system maturation and reduce the incidence of infections and allergic diseases.