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目的:比较观察华蟾素注射液联合化疗与单纯化疗对中晚期食管癌患者的疗效,以提高化疗效果,降低不良反应,改善患者的生活质量。方法:将70例食管癌患者随机分成对照组和治疗组2组,每组各35例,对照组采用化疗(ND)方案单纯化疗法,用含去甲长春花碱(NVB)联合顺氯氨铂(DDP)化疗;治疗组采用联合化疗法,化疗方案与对照组相同,并每天用20 mL华蟾素注射液加入500 mL 5%的葡萄糖注射液,采用静滴方式给药,1周期21 d计,每组患者进行2周期的治疗。2周期治疗后分别以近期疗效、不良反应及生存质量3项作为评价指标,来评价疗效。结果:治疗组和对照组的有效率分别为62.8%,48.5%,经统计分析有显著性差异(P<0.01);生存质量的改善程度也具有显著性差异(P<0.01);治疗组的不良反应发生率低于对照组。结论:华蟾素注射液联合化疗对中晚期食管癌患者化疗的疗效较好,同时降低了不良反应的发生率,改善了患者的生存质量,值得在临床上进一步推广应用。
OBJECTIVE: To compare the efficacy of cinobufagin injection with chemotherapy and chemotherapy alone in the treatment of patients with advanced esophageal cancer to improve the efficacy of chemotherapy, reduce adverse reactions and improve the quality of life of patients. Methods: Seventy patients with esophageal cancer were randomly divided into control group and treatment group, with 35 cases in each group. The control group was treated with chemotherapy (ND) and chemotherapy with NVB plus cisplatin (DDP). The treatment group was treated with combination chemotherapy. The chemotherapy regimen was the same as that of the control group. Each group was given 20 mL of cinobufacini injection with 500 mL of 5% dextrose injection daily, and intravenous infusion of one cycle of 21 d, each group of patients for 2 cycles of treatment. After 2 cycles of treatment, respectively, with short-term efficacy, adverse reactions and quality of life as the evaluation index of 3, to evaluate the efficacy. Results: The effective rates of the treatment group and the control group were 62.8% and 48.5%, respectively, and there was significant difference (P <0.01) by statistical analysis. The improvement of quality of life also had significant difference (P <0.01) The incidence of adverse reactions was lower than that of the control group. Conclusion: Cinobufagin injection combined with chemotherapy is effective in chemotherapy for patients with advanced esophageal cancer. At the same time, it reduces the incidence of adverse reactions and improves the quality of life of patients. It is worth further clinical application.