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目的:观察坦索罗辛联合非那雄胺治疗老年良性前列腺增生(BPH)的效果。方法:选择BPH 102例,随机分为对照组55例和观察组47例。对照组口服盐酸坦索罗辛,观察组在对照组治疗基础上加用非那雄胺。比较两组治疗前后前列腺症状(IPSS)评分、最大尿流率(MFR)、膀胱残余尿量及前列腺体积等的变化情况。结果:两组治疗后IPSS分值、残余尿量值均非常显著低于治疗前(P<0.01);MFR值显著或非常显著高于治疗前P<0.05,P<0.01);前列腺体积治疗前后差异不显著(P>0.05)。观察组治疗后IPSS分值显著低于对照组治疗后(P<0.05),MFR值显著高于对照组治疗后(P<0.05);残余尿量、前列腺体积两组治疗后比较,差异不显著(P>0.05)。结论:坦索罗辛联合非那雄胺治疗老年良性前列腺增生效果优于单用坦索罗辛。
Objective: To observe the effect of tamsulosin plus finasteride in the treatment of benign prostatic hyperplasia (BPH) in elderly patients. Methods: 102 cases of BPH were randomly divided into control group (n = 55) and observation group (n = 47). The control group oral tamsulosin hydrochloride, the observation group in the control group based on the use of finasteride. Prostate symptoms (IPSS) score, maximum flow rate (MFR), residual bladder volume and prostate volume were compared between the two groups before and after treatment. Results: The values of IPSS and residual urine volume after treatment in both groups were significantly lower than those before treatment (P <0.01); MFR was significantly or very significantly higher than before treatment (P <0.05, P <0.01) The difference was not significant (P> 0.05). The IPSS score of the observation group was significantly lower than that of the control group after treatment (P <0.05), and MFR was significantly higher than that of the control group after treatment (P <0.05); residual urine volume and prostate volume were not significantly different after treatment (P> 0.05). CONCLUSION: Tamsulosin plus finasteride is superior to tamsulosin alone in the treatment of elderly patients with benign prostatic hyperplasia.