论文部分内容阅读
T细胞辅助B细胞抗体的生成是体液免疫应答的中心环节。但直到最近,科学家们才对T细胞辅助B细胞的细胞及分子机制有了更清楚的认识。滤泡辅助性T细胞(T follicular helper cells,Tfh)是最近明确的一种新的CD4+T细胞亚群,其主要功能是辅助B细胞参与体液免疫。Tfh的表型和功能与其他CD4+T细胞亚群有所不同,包括趋化因子受体的表达(如CXCR5)、定位和迁移(Tfh存在于B细胞滤泡)及其辅助B细胞的功能。Tfh产生的细胞因子IL-21在Tfh功能中处于核心地位,通过与其受体IL-21R结合,可有效地刺激B细胞分化成抗体形成细胞。因此Tfh细胞相关分子(如ICOS或IL-21)的高表达或低表达,很可能与某些自身免疫性疾病或免疫缺陷疾病的发病有关。
The generation of T cell-assisted B cell antibodies is central to the humoral immune response. Until recently, however, scientists had gained a clearer idea of the cellular and molecular mechanisms of T-helper B cells. T follicular helper cells (Tfh) is a newly identified subpopulation of CD4 + T cells whose primary function is to assist B cells in humoral immunity. The phenotype and function of Tfh is different from that of other CD4 + T cell subsets, including chemokine receptor expression (eg, CXCR5), localization and migration (Tfh is present in B-cell follicles) and its accessory B-cell functions . IL-21, a cytokine produced by Tfh, plays a central role in Tfh function and effectively stimulates B cells to differentiate into antibody-forming cells by binding to its receptor IL-21R. Therefore, the high expression or low expression of Tfh cell-associated molecules (such as ICOS or IL-21) may be related to the pathogenesis of some autoimmune diseases or immunodeficiency diseases.