论文部分内容阅读
目的观察高胰岛素血症对大鼠周围神经和髓鞘的影响。方法通过高脂饲料喂养诱导大鼠产生高胰岛素血症,采用行为学方法观察大鼠痛觉敏感性的变化、电镜观察坐骨神经纤维及髓鞘的变化。结果高脂饲料喂养20d后大鼠出现高胰岛素血症,并表现为胰岛素抵抗,但空腹血糖维持正常;28d后大鼠机械刺激痛敏异常,但热刺激痛敏无明显异常,电镜观察显示大鼠坐骨神经有髓纤维病变比例较普通饲料喂养大鼠明显增加。结论周围神经有髓纤维更容易发生病理性损害,高胰岛素血症可能参与了这一病理过程。
Objective To observe the effect of hyperinsulinemia on peripheral nerve and myelin sheath in rats. Methods Hyperinsulinemia was induced in rats by feeding with high fat diet. The changes of hyperalgesia in rats were observed by behavioral method. The changes of sciatic nerve fibers and myelin sheath were observed by electron microscope. Results After 20 days of high-fat diet, hyperinsulinemia was observed in rats and showed insulin resistance, but the fasting blood glucose remained normal. After 28 days, the rats were mechanically challenged with hyperalgesia, but there was no obvious abnormality of hyperalgesia. Sciatic nerve myelofibrosis rate was significantly higher than the normal diet-fed rats. Conclusion Peripheral nerve myelinated fibers are more prone to pathological damage, hyperinsulinemia may be involved in this pathological process.