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目的:探究血清胱抑素C(CysC)联合视黄醇结合蛋白(RBP)在早期糖尿病肾病诊断中的价值。方法:以90例不同病程的糖尿病患者为观察组,再根据患者病程又分为初诊组、<1年组、1~<6年组及6~12年组;选取同期体检的90例健康人员为对照组,采集2组受检者空腹8h后的外周血清和晨尿,采用免疫比浊法测定血清CysC和尿RBP含量;比较两组不同性别受检者、不同病程糖尿病患者血清CysC、尿RBP的含量及阳性率。结果:观察组患者血清CysC和尿RBP含量均显著高于对照组(P<0.05),对照组被检者未出现血清CysC和尿RBP的阳性结果;观察组患者血清CysC和尿RBP的阳性率分别为42.22%和71.11%,尿RBP的阳性率显著高于血清CysC的阳性率(P<0.05);血清CysC、尿RBP的含量和阳性率随着糖尿病病程的延长而逐渐增高,差异有统计学意义(P<0.05)。结论:糖尿病早期即可出现肾损伤,CysC联合尿RBP检测可为肾脏损伤评估提供参考依据。
Objective: To investigate the value of serum cystatin C (CysC) combined with retinol binding protein (RBP) in the diagnosis of early diabetic nephropathy. Methods: Ninety diabetic patients with different duration were selected as the observation group. According to the duration of the disease, the patients were divided into the newly diagnosed group, <1 year group, 1 ~ <6 years group and 6-12 years group; 90 healthy people As the control group, peripheral blood serum and morning urine were collected after fasting for 8h in both groups. Serum CysC and urinary RBP levels were measured by immunoturbidimetry. Serum CysC and urinary levels were measured in two groups of different gender subjects, RBP content and positive rate. Results: The serum CysC and urinary RBP levels in the observation group were significantly higher than those in the control group (P <0.05). The positive results of serum CysC and urinary RBP were not found in the control group. The positive rates of serum CysC and urinary RBP in the observation group (42.22% and 71.11% respectively). The urinary RBP positive rate was significantly higher than that of serum CysC (P <0.05). The levels of serum CysC, urinary RBP and the positive rate increased with the duration of diabetes mellitus Significance (P <0.05). Conclusion: Kidney injury can occur in the early stage of diabetes mellitus. CysC combined with urinary RBP test can provide a reference for the assessment of renal injury.