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目的:探讨婴儿呼吸道合胞病毒(RSV)急性下呼吸道感染的危险因素。方法:选择2014年10月至2015年12月我院收治的急性下呼吸道感染婴儿1 480例,根据患儿呼吸道分泌物RSV检测结果分为RSV阴性组695例和RSV阳性组785例,比较两组患儿的临床资料和家庭情况,采用多因素Logistics回归分析婴儿RSV急性下呼吸道感染的危险因素。结果:RSV阳性组患儿中,低出生体质量儿、早产儿、秋冬季节感染、有基础疾病史、有先天性心脏病史、家庭常住人口≥4人、父母吸烟、母孕期合并特应性疾病的比例较高,但父母月收入≥1万元、有母孕期高血压疾病史的比例较低,与RSV阴性组比较差异均有统计学意义(P均<0.05)。Logistics回归分析显示,秋冬季节感染[OR=1.589,95%CI(1.175,2.149)]、有先天性心脏病史[OR=1.320,95%CI(1.021,1.707]、母孕期合并特应性疾病[OR=1.833,95%CI(1.229,2.734]是婴儿RSV急性下呼吸道感染的危险因素,父母月收入≥1万元[OR=0.674,95%CI(0.489,0.927]是其保护因素。结论:针对RSV急性下呼吸道感染的危险因素进行干预,可有利于预防和减少RSV急性下呼吸道感染的发生,改善预后,降低病死率。
Objective: To investigate the risk factors of acute lower respiratory tract infection in infants with respiratory syncytial virus (RSV). Methods: A total of 1 480 cases of acute lower respiratory tract infection in our hospital from October 2014 to December 2015 were selected and divided into 695 cases of RSV-negative group and 785 cases of RSV-positive group according to RSV detection results of respiratory secretions in children. Group of children with clinical data and family situation, the use of multi-factor Logistic regression analysis of infant RSV risk factors for acute lower respiratory tract infection. Results: Among the children with RSV positive, low birth weight, premature infants, autumn and winter infection, history of underlying diseases, history of congenital heart disease, family resident population ≥ 4, smoking by parents, atopic pregnancy combined with atopic pregnancy , But their parents’ monthly income was more than RMB 10,000, with a lower proportion of the history of hypertension during the first trimester of pregnancy. There were significant differences between the two groups (all P <0.05). Logistics regression analysis showed that in the fall and winter seasons [OR = 1.589,95% CI (1.175,2.149)], there was a history of congenital heart disease [OR = 1.320,95% CI (1.021,1.707], atopic pregnancy combined with atopic diseases [ OR = 1.833,95% CI (1.229,2.734) is a risk factor for acute lower respiratory tract infection in infants with RSV ≥0.000 [OR = 0.674,95% CI (0.489, 0.927) Aiming at the risk factors of acute lower respiratory tract infection of RSV, it can be helpful to prevent and reduce the incidence of acute lower respiratory tract infection of RSV, improve the prognosis and reduce the mortality.