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体内试验或临床研究表明,免疫毒素(IT)的抗肿瘤作用很不理想。近年该方面最重要的研究领域之一是以化学性或生物性试剂改善IT效能。 亲溶酶体胺类:影响IT效能的最大问题之一是溶酶体酶的降解作用。大部分IT可能被溶酶体酶(核内体和一些大分子)杀灭,仅从溶酶体释出的小部分残余IT才能有效地抑制蛋白合成。氯化铵和氯喹等亲溶酶
In vivo or clinical studies have shown that the anti-tumor effects of immunotoxins (IT) are not ideal. One of the most important areas of research in this area in recent years has been the improvement of IT performance using chemical or biological agents. Pro-lysosomal amines: One of the biggest problems affecting IT efficacy is the degradation of lysosomal enzymes. Most of the IT can be killed by lysosomal enzymes (endosome and some macromolecules), and only a small fraction of residual IT released from lysosomes can effectively inhibit protein synthesis. Ammonium chloride and chloroquine and other lyophilized enzymes