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目的探讨血清C反应蛋白(C-reactive protein,CRP)鉴别诊断小儿社区获得性肺炎(Community-acquired pneumonia,CAP)的效能和临床应用前景。方法收集有关血清CRP鉴别诊断小儿CAP的临床研究进行Meta分析。结果细菌性肺炎患者血清CRP阳性率高于支原体肺炎患者、病毒性肺炎和正常健康人(均P<0.001);支原体肺炎患者血清CRP阳性率亦明显高于病毒性肺炎和正常健康人(均P<0.001);而病毒性肺炎患者血清CRP阳性率则高于正常健康人(P=0.01)。结论细菌性肺炎患者血清CRP显著高于支原体肺炎患者、病毒性肺炎患者及正常健康人。
Objective To investigate the efficacy and clinical application of serum C-reactive protein (CRP) in the diagnosis of community-acquired pneumonia (CAP) in children. Methods Meta-analysis was performed on clinical studies on the differential diagnosis of CAP in children with serum CRP. Results The positive rate of serum CRP in patients with bacterial pneumonia was higher than those in patients with mycoplasma pneumonia, viral pneumonia and normal healthy people (all P <0.001). The positive rate of serum CRP in patients with bacterial pneumonia was also significantly higher than those in patients with viral pneumonia and normal controls <0.001). The positive rate of serum CRP in patients with viral pneumonia was higher than that in healthy controls (P = 0.01). Conclusion The serum CRP in patients with bacterial pneumonia is significantly higher than those in patients with mycoplasma pneumonia, viral pneumonia and normal healthy people.