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为了探讨免疫调质与癫痫发病机制的关系，本文应用免疫细胞化学PAP法对体内和体外实验中马桑内酯（致痫剂）对大鼠大脑皮质种经元白细胞介素-2受体表达的影响进行了研究．在体内实验中，对照经大鼠大脑皮质仅见少量弱阳性白细胞介素-2受体免疫反应神经元，其免疫反应性定位于种经元膜上．大鼠一侧侧脑室注射马桑内酯诱发癫痫后，大脑皮质白细胞介素-2受体阳性神经元明显增多，免疫反应增强．在体外实验中，用马桑内酯温育培养大双皮质神经元24h，其白细胞介素2受体阳性神经元也比对照组增加了1．5倍，免疫染色加深．本实验结果提示，大脑皮质神经元上的白细胞介素-2受体可能参与癫痫的病理机制．
In order to investigate the relationship between immunomodulatory mechanism and the pathogenesis of epilepsy, immunocytochemical PAP method was used to detect the expression of interleukin-2 receptor in rat cerebral cortex by in vivo and in vitro experiments The impact of the study was studied. In in vivo experiments, only a few weak positive IL-2R neurons were detected in the control cerebral cortex of rats, and their immunoreactivity was localized on the meso-membrane. After intracerebroventricular injection of farnesol-induced epilepsy in one side of the rat, the interleukin-2 receptor positive neurons in the cerebral cortex were significantly increased and the immune response was enhanced. In in vitro experiments, the large double cortical neurons were incubated with carnosectone 24h, interleukin 2 receptor positive neurons than the control group also increased by 1.5 times, deepening of immunostaining. The experimental results suggest that interleukin-2 receptor on cerebral cortex neurons may be involved in the pathogenesis of epilepsy.