目的　介绍国内外研制的一些糖皮质激素前体药物。方法　分别以糖苷、糖苷酸、葡聚糖和多聚氨基酸为载体 ,着重分析了它们在实验动物中的药物代谢和药效学情况。结果　这些前体药物均具有结肠定位功能 ,并能增强糖皮质激素的药效或降低不良反应。结论　这些前体药物具有治疗结肠炎的潜力 ,并提出以植物多糖做载体的可能性 Objective To introduce some glucocorticoid prodrugs developed at home and abroad. Methods The glycosides, glycosides, dextran and polyamino acids were used as carriers respectively, and their metabolism and pharmacodynamics in experimental animals were analyzed emphatically. As a result, these prodrugs have colonic function and can enhance glucocorticoid efficacy or reduce adverse reactions. Conclusions These prodrugs have the potential of treating colitis and suggest the possibility of using plant polysaccharides as a carrier