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本文报道用人白细胞干扰素治疗2名疣状表皮结构不良病人皮肤癌的效果,所用干扰素活性为100单位/毫克蛋白。一例患者为32岁男性,从2岁开始患与人乳头状病毒5型(HPV5)有关的花斑癣样损害。近来,在其手掌、臀部、大腿和阴囊等处出现了多个肿瘤。鱼际处为一大的侵袭性鳞状细胞癌,其他为原位癌,均作了外科切除。口服维生素甲酸 Ro10-93591毫克/公斤/日,使阴囊上一些小的剩余肿瘤得到治愈,花斑癣样损害亦有改善,其中的病毒含量减少。但
This article reports the effect of human leukocyte interferon on the treatment of skin cancer in two patients with sickle-like epidermal dysplasia. The activity of interferon used is 100 units/mg protein. One patient, a 32-year-old man, developed tinea versicolor-like lesions associated with human papillomavirus type 5 (HPV5) from the age of 2 years. Recently, multiple tumors have appeared in the palms, buttocks, thighs and scrotum. There was a large invasive squamous cell carcinoma at the interthenar and other cases were carcinoma in situ and surgically removed. Oral vitamin formate Ro10-93591 mg/kg/day resulted in the healing of some small residual tumors in the scrotum, and improved tinea versicolor lesions in which the virus content was reduced. but