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目的：研究卡维地洛对麻醉兔希氏束电活动和心电活动的影响。方法：采用左心导管法记录IIBE，同步记录Ⅱ导联ECG,并与普萘洛尔进行比较。结果：卡维地洛在0．01，0.11，3，6，9mg·kg－1时分别减慢HR（%）：9．1±4．8，21．3±3．0，30．7±4．0，35.4±5．6，40．0±6．0，42．5±6.1；延长P－R间期（％）：1．8±3．0，5．4±4．9，10．0±7．4，16.8±8．4，25．7±9．3，33．6±12．4；延长A－H间或（％）：5．6±4．8，10．9±6．4，16．5±6．2，24．2±7．7，31．6±10．8，20．6±15．0延长H－V间期（％）：5．1±5．4，8．7±5．3，14．9±5．7，21．2±9．5，27．1±11．2，39．9±9．4增宽Ⅴ波（%）：2．0±42，3．8±3．9，7．8±7．1,15．6±11．0，37．0，37．0±2．4。结论：在同一累积剂量，卡维地治和普菲洛尔对心脏的抑制作用基本相同，卡维地洛可能比普蒂洛尔更适合治疗心血管系统疾病。但对已有心动过缓和心脏传导阻滞的患者，临床应用时仍应注意卡维地洛的心脏抑制作用。
Objective: To study the effect of carvedilol on His electrical activity and cardiac electrical activity in anesthetized Rabbits. Methods: IIBE was recorded by left heart catheterization, and ECG of Ⅱ lead was recorded synchronously and compared with propranolol. Results: Carvedilol slowed HR (%) at 0.01,0.11,3,6,9mg · kg-1 respectively: 9.1 ± 4.8, 21.3 ± 3.0, 30.7 ± 4.0, 35.4 ± 5.6, 40.0 ± 6.0, 42.5 ± 6.1; prolonged P-R interval (%): 1.8 ± 3.0, 5.4 ± 4.9 , 10.0 ± 7.4, 16.8 ± 8.4, 25.7 ± 9.3, 33.6 ± 12.4; prolongation of A-H or (%): 5.6 ± 4.8,10. 9 ± 6.4, 16.5 ± 6.2, 24.2 ± 7.7, 31.6 ± 10.8, 20.6 ± 15.0 Intermittent H-V interval (%): 5.1 ± 5.4,8.7 ± 5.3,14.9 ± 5.7,21.2 ± 9.5,27.1 ± 11.2,39.9 ± 9.4 Widening Ⅴ wave (% ): 2.0 ± 42,3.8 ± 3.9,7.8 ± 7.1,15.6 ± 11.0,37.0,37.0 ± 2.4. CONCLUSION: Carvedilol may be more suitable than ptyolol for the treatment of cardiovascular diseases at the same cumulative dose, with carvedilol and pofeiolol at their heart. However, there have been bradycardia and heart block in patients with clinical application of carvedilol should still pay attention to the heart inhibition.