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目的 评价磁共振灌注成像 (PWI)在后颅凹肿瘤的诊断和鉴别诊断中的价值。方法 本组 3 7例后颅凹肿瘤病人行双倍剂量PWI,求出肿瘤和脑白质的相对脑血流容积 (rCBV)和平均通过时间 (MTT) ,计算肿瘤与脑白质的rCBV之比QrCBV、肿瘤的MTT较白质的延长值rMTT。结果 血管母细胞瘤的血流灌注最高 ,明显高于其它肿瘤。转移瘤的QrCBV和rMTT变化范围较大 ,与其它肿瘤不易区别。髓母细胞瘤的QrCBV高于毛细胞型星形细胞瘤和室管膜瘤 ,但后两者间无显著统计学差异。脑膜瘤和神经源性肿瘤较脑内原发性肿瘤的rMTT明显延长。结论 PWI在后颅凹肿瘤的诊断和鉴别诊断中具有重要价值 ,可作为常规MRI检查的补充
Objective To evaluate the value of magnetic resonance perfusion imaging (PWI) in the diagnosis and differential diagnosis of posterior fossa tumors. Methods Thirty-seven patients with posterior fossa tumors underwent double-dose PWI. The relative cerebral blood flow volume (rCBV) and mean transit time (MTT) of tumors and white matter were calculated to calculate the ratio of rCBV between tumors and white matter QrCBV , Tumor MTT white matter than the extension of rMTT. The results of hemangioblastoma blood perfusion was highest, significantly higher than other tumors. Metastatic tumor QrCBV and rMTT range of changes, and other tumors is not easy to distinguish. The QrCBV of medulloblastoma was higher than that of hairy cell type astrocytoma and ependymoma, but there was no significant difference between the latter two groups. Mesentery and neurogenic tumors than the primary brain tumor rMTT was significantly prolonged. Conclusions PWI is of great value in the diagnosis and differential diagnosis of posterior fossa tumors and can be used as a supplement to conventional MRI