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目的探讨不同糖耐量水平妊娠妇女血清中CRP、血脂与血糖的关系及临床意义,为妊娠糖尿病(GDM)的二级预防提供实验室依据。方法对正常妊娠组、妊娠糖尿病组和糖耐量受损组利用奥林帕斯AU400全自动生化分析仪进行空腹血糖(FPG)、糖筛查实验(GCT)、口服葡萄糖耐量实验(OGTT)和C-反应蛋白(CRP)及血脂检测,并对结果进行回顾性分析。结果显示随着血糖的升高,患者血清CRP水平也随之升高。不同血糖异常阶段合并血脂异常的特点也不同,糖耐量正常(NGT)组,糖耐量异常(IGT)组及妊娠糖尿病(GDM)组的甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)的水平依次递增,而高密度脂蛋白胆固醇(HDL-C)水平则呈递减趋势,血脂以高TG、TC、LDL-C为主。结论CRP和血脂检测对妊娠糖尿病(GDM)的孕妇很重要,结合血糖应进行跟踪随访,动态观察,对异常结果应早期进行必要的预防治疗,减少或延缓其向2型糖尿病发展。
Objective To investigate the relationship and clinical significance of serum levels of CRP, lipids and blood glucose in pregnant women with different glucose tolerance levels and to provide a laboratory basis for secondary prevention of gestational diabetes mellitus (GDM). Methods Normal pregnancy group, gestational diabetes mellitus group and impaired glucose tolerance group were subjected to fasting plasma glucose (FPG), sugar screening test (GCT), oral glucose tolerance test (OGTT) and C - Reactive protein (CRP) and serum lipids, and the results were retrospectively analyzed. The results showed that with the rise of blood glucose, serum CRP levels also increased. The features of dyslipidemia in different stages of abnormal blood glucose are also different. TG, TC, LDL of IGT group, IGT group and GDM group are different, The level of LDL-C increased gradually, while the level of HDL-C decreased gradually. The level of serum lipids was high TG, TC and LDL-C. Conclusion The detection of CRP and serum lipids in pregnant women with gestational diabetes mellitus (GDM) is very important. Combined with blood glucose, they should be followed up and observed dynamically. Early diagnosis and treatment of abnormal results should be made to reduce or delay the development of type 2 diabetes mellitus.