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目的观察腹部外科手术病例进行术前糖预处理及应用新的禁食方案等治疗方法对减轻术后胰岛素抵抗的价值。方法对2003年3月至2004年12月采用Quicki法测定191例腹部手术后病人胰岛素敏感性,前瞻性对比术前进行糖预处理及应用新的禁食方案病例组(88例)与对照组(103例)在术后胰岛素抵抗方面的差异,以t检验比较两组间差异的显著性。结果治疗组术后胰岛素抵抗程度及持续时间均明显低于对照组(P<0.05)。结论腹部手术后早期胰岛素抵抗是机体应激反应的表现,手术后长时间胰岛素抵抗不利于术后恢复。术前糖预处理治疗可有效降低围手术期胰岛素抵抗程度,缩短胰岛素抵抗时间,有助于病人早期康复。
Objective To observe the value of preoperative glucose pretreatment and application of new fasting regimen in the treatment of abdominal surgery to reduce the postoperative insulin resistance. Methods From March 2003 to December 2004, Quicki method was used to determine the insulin sensitivity of 191 patients undergoing abdominal surgery. Prospectively compared with pretreatment of glucose pretreatment and application of new fasting regimen (88 cases) and control group (103 cases) in the postoperative insulin resistance, t test was used to compare the difference between the two groups was significant. Results The postoperative insulin resistance and the duration of treatment in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion Early post-abdominal surgery, insulin resistance is the manifestation of stress response. Long-term insulin resistance after surgery is not conducive to postoperative recovery. Preoperative treatment of glucose pretreatment can effectively reduce the perioperative insulin resistance, shorten the insulin resistance time, help patients early rehabilitation.