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目的探讨CA199在良性梗阻性肝胆疾病患者血清中的变化及临床意义。方法对123例良性梗阻性肝胆疾病患者在入院和经治疗出院时分别进行血清CA199、总胆红素(TBil)、直接胆红素(DBil)、丙氨酸氨基移换酶(ALT)、天门冬氨酸氨基移换酶(AST)、碱性磷酸酶(ALP)检测，分析其变化。另设66名健康体检者作为对照组。结果病例组血清CA199、TBil、DBil、ALT、AST、ALP水平均显著高于对照组(<0.01)，经治疗CA199水平随TBil、DBil水平下降而下降，治疗前后CA199水平有显著差异(P<0.01)。结论在良性梗阻性肝胆疾病患者血清中CA199水平可明显增高。 CA199不能作为梗阻性肝胆疾病良恶性的判断依据，只有和其他指标联合应用才具临床意义。“,”Objective To investigate the changes of serum CA199 in patients with benign obstructive hepatobiliary diseases and its clinical significance. Methods The serum CA199,total bilirubin(TBil), direct bilirubin(DBil),alanine amino removed enzyme(ALT),aspartate amino removed enzyme(AST),the alkalinity phosphatase(ALP)of 123 patients with benign obstructive hepatobiliary diseases were detected when in hospital and after treatment out of hospital.Analysis of the changes.Set ing up 66 healthy physical examination as control group.Results The case group of serum CA199,TBil,DBil,ALT,AST,ALP levels were significantly higher than those in control group ( <0.01)After treatment with TBil and DBil decreased,the levels of CA199 decreased.The level of CA199 before and after treatment,there were significant dif erences ( <0.01).Conclusion The level of CA199 in serum of patients with benign obstructive hepatobiliary diseases can significantly increase.CA199 cannot be used as a judgment basis of benign and malignant obstructive hepatobiliary disease,Only joint detection with other indicators to be clinical significance.