急性乙型肝炎感染乙型肝炎病毒(HBV)是非细胞致病性的。肝脏的损害是感染的肝细胞免疫溶解所致。在炎性浸润性细胞中,有自然杀伤(NK)和细胞毒性T细胞。在肝细胞表面有、病毒抗原。这些抗原协同Ⅰ类主要组织相容复合体(MHC)蛋白质,使这些细胞成为细胞毒性T细胞溶解的靶细胞。对慢性HBV感染病人的研究提示,乙型肝炎核心(C)和e抗原是免疫系统主要的靶抗原。肝细胞通常只表达微量Ⅰ类MHC糖蛋白,但在急性HBV感染早期,随着干扰素 Acute Hepatitis B Infection Hepatitis B virus (HBV) is non-cytopathic. Damage to the liver is caused by immunolysis of the infected liver cells. Among inflammatory infiltrating cells are natural killer (NK) and cytotoxic T cells. On the surface of liver cells, viral antigens. These antigens work in conjunction with class I major histocompatibility complex (MHC) proteins, making these cells the target cells for cytotoxic T cell lysis. Studies of patients with chronic HBV infection suggest that the hepatitis C core (C) and e antigen are the major target antigens of the immune system. Liver cells usually express only trace amounts of class I MHC glycoproteins, but early in acute HBV infection, with interferon