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成纤维细胞生长因子(FGF)是一种广泛分布于角膜、视网膜及玻璃体等眼组织中具有促进细胞分裂作用的两性蛋白质。碱性FGF 是由146个氨基酸组成的单链多肽,分子量16kDa;酸性 FGF 是由140个氨基酸组成的单链多肽,有两个微观不均一的形式,分子量分别为16.6和16.8kDa。FGF 在机体的组织修复、血管生成和创伤愈合的病理生理过程中起重要作用。由于 FGF 与细胞及细胞外基质的相互作用,因此在促进角膜损伤的愈合,修复因营养不良、变性和外科手术引起的角膜内皮细胞丧失,促使白内障术后晶状体细
Fibroblast growth factor (FGF) is an amphipathic protein that is widely distributed in cornea, retina, and vitreous tissues and promotes cell division. Basic FGF is a single-chain polypeptide consisting of 146 amino acids and has a molecular weight of 16 kDa. Acid FGF is a single-chain polypeptide consisting of 140 amino acids and has two micro-inhomogeneous forms with molecular weights of 16.6 and 16.8 kDa, respectively. FGF plays an important role in the pathophysiological process of tissue repair, angiogenesis and wound healing in the body. Due to the interaction of FGF with cells and extracellular matrix, it promotes the healing of corneal injury, repairs the loss of corneal endothelial cells due to malnutrition, degeneration and surgery, and promotes the phacoemulsification of the lens after cataract surgery.