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桥本甲状腺炎(HT)是一种常见的器官特异性的自身免疫性疾病,实验性自身免疫性甲状腺炎(EAT)是研究HT的动物模型。在HT与EAT的发病过程中,Th1/Th2细胞免疫失衡发挥着重要作用,表现为Th1细胞因子亢进占优势。Th1细胞可加重炎性反应,而Th2细胞发挥抗炎作用,纠正HT患者体内失衡的细胞因子可以起到一定的治疗作用。
Hashimoto’s thyroiditis (HT) is a common organ-specific autoimmune disease. Experimental autoimmune thyroiditis (EAT) is an animal model for studying HT. In the pathogenesis of HT and EAT, Th1 / Th2 cell immune imbalance play an important role, manifested as Th1 cytokine hyperthyroidism dominant. Th1 cells can exacerbate the inflammatory response, and Th2 cells play an anti-inflammatory role, to correct the imbalance of cytokines in HT patients may play a therapeutic role.