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目的探讨辛伐他汀对短暂性脑缺血发作(TIA)患者颈动脉粥样硬化斑块(AP)的影响。方法将86例明确伴有颈动脉AP的TIA患者随机分为研究组及对照组;研究组口服辛伐他汀及阿斯匹林肠溶片,对照组仅口服阿斯匹林肠溶片;于治疗前、治疗2及8个月后进行颈动脉超声检查,测颈动脉内-中膜厚度(IMT)、AP面积、数量,并观察治疗期间2组患者脑血管病的发生情况。结果与治疗前及对照组比较,研究组治疗8个月后颈动脉IMT变薄及AP面积、数量均明显减少,差异均有统计学意义(P<0.05),但治疗2个月后上述指标与治疗前比较,差异均无统计学意义(P>0.05);治疗8个月后研究组脑血管病的发生率与对照组比较,差异无统计学意义(P>0.05)。结论较长时间服用辛伐他汀能有效稳定TIA患者的颈动脉AP。
Objective To investigate the effect of simvastatin on carotid atherosclerotic plaque (AP) in patients with transient ischemic attack (TIA). Methods Eighty-six TIA patients with definite carotid AP were randomly divided into study group and control group. The study group was given simvastatin and aspirin enteric-coated tablets, and the control group only received aspirin enteric-coated tablets. Carotid ultrasonography was performed 2 and 8 months after treatment. The IMT, AP area and number of the carotid arteries were measured before and after treatment. The incidence of cerebrovascular disease in both groups was also observed. Results Compared with before treatment and control group, carotid artery IMT thinning and AP area and number were significantly decreased in study group after 8 months of treatment, the difference was statistically significant (P <0.05), but after 2 months of treatment, the above indexes Compared with those before treatment, the difference was not statistically significant (P> 0.05). After 8 months of treatment, the incidence of cerebrovascular disease in the study group was not significantly different from that in the control group (P> 0.05). Conclusion Long-term administration of simvastatin can effectively stabilize the carotid artery AP in TIA patients.