乳腺癌是欧洲及北美洲妇女最常见的恶性肿瘤。引起乳腺癌的原因除其它因素外,最明显的是家族史。有乳腺癌家族史的妇女发病显著高于正常人群。通过流行病学及遗传病学的调查表明,大约5％的乳腺癌患者是由于基因突变引起,如果一个家族中有2个以上年龄<50岁乳腺癌患者,此家族中的妇女发生基因突变的危险性明显上升。这就给我们提出了严肃的问题,是否通过药物来降低这些妇女发病的危险。 Breast cancer is the most common malignancy of women in Europe and North America. Causes of breast cancer, among other factors, the most obvious is the family history. The incidence of women with a family history of breast cancer was significantly higher than that of the normal population. According to epidemiological and genetic studies, approximately 5% of breast cancer patients are caused by genetic mutations. If a family has more than 2 breast cancer patients <50 years of age, women in this family have a genetic mutation. The risk has risen significantly. This poses serious questions to us about whether to reduce the risk of these women’s morbidity through drugs.