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目的：探讨Ｂｉｎｓｗａｎｇｅｒ病患者免疫功能的变化。方法：疾病组和对照组各２３例，分别检测外周血和脑脊液体液、细胞免疫系列指标。结果：与对照组比较，疾病组外周血抗心磷脂抗体阳性率明显升高，脑脊液ＩｇＧ指数明显升高。疾病组与对照组间脑脊液淋巴细胞亚群存在显著差异。两组间其它免疫指标无显著差异。结论：Ｂｉｎｓｗａｎｇｅｒ病患者中枢神经系统内可能存在免疫应答异常。
Objective: To investigate the changes of immune function in patients with Binswanger’s disease. Methods: The disease group and the control group of 23 cases were detected in peripheral blood and cerebrospinal fluid humoral, cellular immune indicators. Results: Compared with the control group, the positive rate of peripheral blood anticardiolipin antibodies in the disease group was significantly increased, and the IgG index in cerebrospinal fluid was significantly increased. Significant differences were found in the cerebrospinal fluid lymphocyte subsets between the disease group and the control group. There was no significant difference in other immune parameters between the two groups. Conclusion: There may be abnormal immune response in central nervous system of Binswanger’s disease.