卡马西平是一种三环化合物类抗惊厥药物,亦称酰胺咪嗪,临床上主要用于抗癫痫以及抗外周神经痛、抗利尿、抗躁狂等。常见不良反应有中枢神经系统的反应,表现为视物模糊、复视、眼球震颤;以及因刺激抗利尿激素分泌引起的水潴留和低钠血症;少见皮疹、荨麻疹、大疱性表皮坏死性松解型药疹,但致严重心律失常较罕见。现将笔者遇见的卡马西平致严重心律失常2例报道如下。1病例资料病例1:男,79岁,因左侧肢体不自主抽搐1周入院。既往 Carbamazepine is a tricyclic compound anticonvulsant drugs, also known as amidipramine, clinically used mainly for anti-epilepsy and anti-peripheral nerve pain, anti-diuretic, anti-mania and so on. Common adverse reactions are central nervous system reactions, manifested as blurred vision, diplopia, nystagmus; and due to stimulation of antidiuretic hormone secretion caused by water retention and hyponatremia; rare rash, urticaria, epidermal necrosis of the bullous Sexually-degraded drug eruption, but severe arrhythmias are rare. Now the author met with carbamazepine serious arrhythmia reported in 2 cases are as follows. Case data Case 1: Male, 79 years old, involuntary convulsions in the left limb were admitted to hospital for 1 week. Past