论文部分内容阅读
葛花是野葛Pueraria lobata Ohwi的花。用于解酒,醒酒,厌食,呕吐等。葛花解醒汤为汉方中醒酒的代表方剂。本文报道葛花中的甲醇提取物(PF-ME)4及其分离所得的黄酮部分(PF-lF),二萜皂甙(PF-SP)与色氨酸衍生物(PF-P)等成分对乙醇诱发的代谢异常与二种实验性肝损模型(CCl_4与高脂食物引起的肝损小鼠)的影响,以阐明葛花醒酒的药理作用。实验样品的制备流程见下图:
Ge Hua is the flower of Pueraria lobata Ohwi. For hangover, sobering, anorexia, vomiting and so on. Gehua Jiexue Decoction is a representative formula for sobering in the Chinese side. In this paper, the methanol extract (PF-ME) 4 in Pueraria lobata and its isolated flavonoids (PF-lF), diterpene saponins (PF-SP) and tryptophan derivatives (PF-P) are reported. Ethanol-induced metabolic abnormalities and the effects of two experimental liver injury models (CCl_4 and liver damage mice caused by high-fat foods) were used to elucidate the pharmacological effects of Gehua sobering. The preparation process of the experimental sample is shown in the figure below: