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目的:研究自制复方芦荟乳膏对豚鼠日晒伤的治疗作用。方法:采用SUV-1000日光紫外模拟器为辐射装置照射豚鼠脱毛区制备豚鼠中度日晒伤模型。雌性白化豚鼠72只,随机分成6组,分别为模型组、芦荟晒伤膏空白基质组、京万红组、复方芦荟乳膏低剂量组、中剂量组、高剂量组。连续给药7d,每天3次,每次用药量约为0.14g。给药7d后,测量并计算创面愈合率,并进行组织病理学检查。结果:芦荟晒伤膏空白基质组、京万红组、复方芦荟乳膏低剂量组、中剂量组、高剂量组创面愈合率与模型组比较均有显著提高(P<0.01),复方芦荟乳膏高剂量组与市售京万红组无显著性差异。结论:复方芦荟乳膏对豚鼠日晒伤有治疗作用,且具有色泽浅、中药味淡、清爽不油腻等优点。
Objective: To study the therapeutic effect of homemade aloe vera cream on sun-damaged guinea pigs. Methods: The SUV-1000 solar-powered external mock-up was designed to take care of baby’s eye during phototherapy. A total of 72 female albino guinea pigs were randomly divided into 6 groups: model group, Aloe vera sunburn cream blank matrix group, Jinghonghong group, compound aloe vera cream low dose group, middle dose group and high dose group. Continuous administration of 7d, 3 times a day, each dose of about 0.14g. After 7 days of administration, the wound healing rate was measured and calculated and histopathological examination was performed. Results: The wound healing rate of blank matrix group, Jing Wanhong group, Aloe vera cream low dose group, medium dose group and high dose group were significantly higher than those of model group (P <0.01) There was no significant difference between high-dose cream group and Jing-Wan-Hong group. Conclusion: Aloe vera cream has a therapeutic effect on sunburn in guinea pigs, and has the advantages of light color, light traditional Chinese medicine, fresh and not greasy.