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目的观察中心静脉导管留置灌注白介素-2治疗恶性胸腔积液临床疗效,探讨此技术在治疗中的应用价值。方法收集临床已确诊患有胸腔积液并行胸膜腔留置中心静脉导管的患者66例。待胸腔积液基本引流完后生理盐水50～60 ml,DDP 50 mg/m2,白细胞介素-II 200万U,地塞米松注射液10 mg,充分溶解后注入胸腔,闭管2～3 d后再引流积液,注药为每周1次,共2～4次。观察疗效、生活质量和毒副反应。结果留置中心静脉导管灌注白介素-2联合顺铂治疗恶性胸水总有效率达91.8%。胸膜腔留置中心静脉导管操作简便,患者痛苦小,便于胸水引流及注药,医生工作量明显降低。结论留置中心静脉导管灌注白介素-2联合顺铂治疗恶性胸水疗效好,方便、安全,可以作为治疗恶性胸腔积液的有效方法。
Objective To observe the clinical efficacy of intravenous catheter infusion of interleukin-2 in the treatment of malignant pleural effusion and to explore the value of this technique in the treatment. Methods Sixty-six patients with clinically diagnosed patients with pleural effusion and central venous catheters were collected. After the basic drainage of pleural effusion after 50 to 60 ml of normal saline, DDP 50 mg / m2, interleukin-II 200 million U, dexamethasone injection 10 mg, fully dissolved into the chest, closed 2 ~ 3 d Fluid drainage after drainage, injection for the weekly 1, a total of 2 to 4 times. Observation of efficacy, quality of life and side effects. Results indwelling central venous catheter interlukin-2 combined with cisplatin in the treatment of malignant pleural effusion, the total effective rate was 91.8%. Pleural cavity indwelling central venous catheter easy to operate, the patient pain is small, easy pleural effusion and injection, the doctor workload was significantly reduced. Conclusion Indwelling central venous catheter infusion of interleukin-2 combined with cisplatin in the treatment of malignant pleural effusion is effective, convenient and safe and can be used as an effective method for the treatment of malignant pleural effusion.