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对３５例耳、肾功能正常的下呼吸道细菌感染患者采用阿米卡星全日剂量单次给药评价其临床疗效及不良反应。结果表明，单次用药疗效与二次用药比较无明显差异。单次用药治疗前、后肾功能无明显变化，２例患者出现听力下降，但２周内恢复正常。二次用药治疗后３例病人尿β２－微球蛋白（β２－ＭＧ）、血α１－微球蛋白（α１－ＭＧ）出现异常变化；２例出现感音神经性耳聋患者１月内未恢复正常。提示：在获得满意疗效的同时，为有效降低不良反应，１５ｍｇ／ｋｇ全日剂量单次用药对患者更为有利。
To evaluate the clinical efficacy and side effects of amikacin single-dose administration in 35 patients with lower respiratory tract bacterial infection with normal ear and kidney function. The results showed that the single drug efficacy and no significant difference between the two drugs. No significant change in renal function was observed before and after single-dose treatment, and hearing loss occurred in 2 patients but returned to normal within 2 weeks. Urinary β2-microglobulin (β2-MG) and α1-microglobulin (α1-MG) were abnormal in 3 patients after secondary drug treatment; 2 patients with sensorineural deafness did not recover within 1 month . Tip: In the same time to obtain a satisfactory effect, in order to effectively reduce adverse reactions, 15mg / kg full-time single-dose medication is more favorable for patients.