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目的:探讨X连锁凋亡抑制蛋白(XIAP)和血管内皮生长因子(VEGF)在子痫前期患者胎盘和血清中的表达及其意义。方法:采用ELISA法和SABC技术测定20例正常妊娠孕妇为对照组和30例子痫前期患者为子痫前期组(其中轻度子痫前期患者20例,重度子痫前期患者10例)胎盘及血清中XIAP、VEGF的表达情况。结果:①子痫前期疾病组血清中XIAP、VEGF表达均显著降低(P<0.01),且XIAP、VEGF在轻度子痫前期患者的表达要高于重度子痫前期患者。②血清中XIAP与VEGF的表达呈正相关。③轻度和重度子痫前期组胎盘组织中XIAP、VEGF的阳性表达率均低于对照组,轻度子痫前期组与对照组比较差异有统计学意义(P<0.01),重度子痫前期组与轻度组相比,差异有统计学意义(P<0.01)。结论:XIAP、VEGF可能均参与了子痫前期疾病的发病机制。XIAP可能通过VEGF对子痫前期患者的调节,发生XIAP表达降低而对子痫前期患者产生影响。
Objective: To investigate the expression and significance of X-linked inhibitor of apoptosis protein (XIAP) and vascular endothelial growth factor (VEGF) in placenta and serum of preeclampsia patients. Methods: Twenty normal pregnant women and 30 pregnant women with preeclampsia were enrolled in this study. The placenta and serum of 20 preeclampsia patients (20 mild preeclampsia patients and 10 severe preeclampsia patients) were detected by ELISA and SABC technique. In XIAP, VEGF expression. Results: ① The serum levels of XIAP and VEGF in preeclampsia group were significantly lower than those in severe preeclampsia (P <0.01), and the expression of XIAP and VEGF in patients with mild preeclampsia was higher than that in severe preeclampsia. ② Serum XIAP and VEGF expression was positively correlated. ③ The positive expression rate of XIAP and VEGF in mild and severe preeclampsia group was lower than that in control group, the difference between mild preeclampsia group and control group was statistically significant (P <0.01), severe preeclampsia Compared with mild group, the difference was statistically significant (P <0.01). Conclusion: XIAP and VEGF may all participate in the pathogenesis of preeclampsia. XIAP may affect the preeclampsia patients through the regulation of VEGF in patients with preeclampsia and the decrease of XIAP expression.