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目的:探讨年龄、受精方式、胚胎冷冻方法及胚胎冻存时间对冻融胚胎存活的影响。方法:回顾分析冻融胚胎移植(FET)1255个周期,根据年龄、受精方式、胚胎冷冻方法及胚胎冻存时间进行分组,比较各组的冻融胚胎存活率、完全存活率及临床妊娠率。结果:玻璃化冷冻组冻融胚胎存活率、完全胚胎存活率及临床妊娠率分别为93.4%、95.9%、48.8%,程序化冷冻组冻融胚胎存活率、完全胚胎存活率及临床妊娠率分别为81.2%、54.9%、30.1%,两组差异有统计学意义(P<0.05);年龄、受精方式、胚胎冻存时间对冻融胚胎存活率及完全胚胎存活率无明显影响(P>0.05)。结论:玻璃化冷冻胚胎技术比程序化冷冻胚胎技术能获得更高的冻融胚胎存活率、完全胚胎存活率及临床妊娠率,3年内的冻融胚胎可不考虑冻存时间对胚胎存活的影响。
Objective: To investigate the effects of age, fertilization method, embryo freezing method and embryo cryopreservation on survival of frozen-thawed embryos. Methods: 1255 cycles of frozen-thawed embryo transfer (FET) were retrospectively analyzed. The age, fertilization method, embryo freezing method and embryo cryopreservation time were used to analyze the survival rate, complete survival rate and clinical pregnancy rate of each group. Results: The survival rate, complete embryo survival rate and clinical pregnancy rate of frozen-thawed embryos in vitrification group were 93.4%, 95.9% and 48.8% respectively. The frozen-thawed embryo survival rate, complete embryo survival rate and clinical pregnancy rate (81.2%, 54.9%, 30.1% respectively). There was significant difference between the two groups (P <0.05). Age, fertilization and embryo cryopreservation time had no significant effect on the survival rate of frozen-thawed embryos and the rate of complete embryo survival ). CONCLUSION: Frozen-thawed embryo technology achieves higher survival rate of frozen-thawed embryo, complete embryo survival rate and clinical pregnancy rate than programmed freezing embryo technology. Frozen-thawed embryo within 3 years can not consider the effect of cryopreservation time on embryo survival.