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目的 探讨胃左动脉区域灌注化疗治疗胃癌的合理性。方法比较氟尿嘧啶（５－ＦＵ）经胃左动脉和外周静脉给药后的药代动力学变化。结果胃左动脉给药组的门静脉血中５－ＦＵ浓度为外周静脉给药组的４～２００倍，而且５－ＦＵ高浓度的维持时间明显延长；癌组织和癌旁淋巴组织中５－ＦＵ水平分别为静脉给药组的１９倍和２３倍。结论胃左动脉区域灌注化疗可明显增加癌肿局部的化疗药物浓度，提高化疗疗效。
Objective To investigate the rationality of regional gastric infusion chemotherapy for gastric cancer. Methods The pharmacokinetics of 5-fluorouracil (5-FU) administered via the left gastric artery and peripheral vein were compared. Results The concentration of 5-FU in the portal vein blood of the left gastric artery administration group was 4 to 200 times that of the peripheral intravenous administration group, and the maintenance time of 5-FU high concentration was significantly prolonged; 5-FU in the cancer tissue and paracancerous lymphoid tissues was observed. The levels were 19 and 23 times that of the intravenous administration group, respectively. Conclusion Regional infusion of the left gastric artery can significantly increase the concentration of chemotherapeutic drugs in local cancer and improve the efficacy of chemotherapy.