哌替啶对热空气烧伤大鼠气管血管通透性的增加呈明显抑制作用,且使气管MDA含量显著下降、SOD活性逐渐显著提高。纳洛酮对哌替啶抑制气管血管通透性的作用无明显影响。提示,哌替啶抑制气管血管通透性的作用与对纳洛酮敏感的阿片受体无关;提高SOD活性以增强清除O_2~-·的能力,减少活性氧的生成,抑制脂质过氧化反应,可能是其作用机理的一方面。 Pethidine significantly inhibited the increase of tracheal vascular permeability in hot air burn rats, and significantly decreased the content of MDA in trachea and the activity of SOD gradually increased. Naloxone had no significant effect on the pethidine inhibition of tracheal vascular permeability. It is suggested that the pethidine inhibit the tracheal vascular permeability has nothing to do with the naloxone sensitive opioid receptor; improve the activity of SOD to enhance the ability to scavenge O 2 - - · · ·, reduce the generation of reactive oxygen species, inhibit lipid peroxidation , May be one aspect of its mechanism of action.