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本文应用石蜡切片免疫组化ＰＡＰ法，回顾性观察了６１例直肠中分化管状腺癌组织ＥＲ、ＰＲ表达情况。ＥＲ（＋）／ＰＲ（＋）为４２．６％；ＥＲ（－）／ＰＲ（－）为５７．４％。ＥＲ／ＰＲ的存在表明该癌组织具有了依赖性激素的特性。ＥＲ（＋）／ＰＲ（＋）者的中位生存期为４．５年，一、三、五年生存率为８８．５％、５３．９％、３８．５％，均高于ＥＲ（－）／ＰＲ（－）者的生存率。 ＥＲ（－）／ＰＲ（－）者的中位生存期为２．４年，一、三、五年生存率为６５．７％、４２．８％、２８．６％。表达阳性与阴性两者的生存期有明显差异（Ｐ＜０．０１）。检测ＥＲ／ＰＲ受体亦可做为判定预后的指标之一。本实验证实ＥＲ、ＰＲ表达与年龄、性别以及ＬＮＭ之间无明显差异（Ｐ＞０．０５）。
Paraffin section immunohistochemical PAP method was applied in this study. The expression of ER and PR in 61 cases of rectal differentiated tubular adenocarcinoma was retrospectively observed. ER(+)/PR(+) was 42.6%; ER(-)/PR(-) was 57.4%. The presence of ER/PR indicates that the cancer tissue has a hormonal dependence. The median survival of ER(+)/PR(+) was 4.5 years, and the 1-, 3-, and 5-year survival rates were 88.5%, 53.9%, and 38.5%, both higher than those of ER ( -)/PR (-) survival rate. The median survival of ER(-)/PR(-) was 2.4 years, and the one-, three-, and five-year survival rates were 65.7%, 42.8%, and 28.6%. There was a significant difference between the positive and negative expressions (P<0.01). Detection of ER/PR receptors may also serve as one of the indicators of prognosis. This experiment confirmed that there was no significant difference between ER, PR expression and age, sex, and LNM (P>0.05).