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2-巯基苯并咪唑(2-MBI)是橡胶生产过程中的一种加速剂和/或抗氧化剂,因其结构与抗甲状腺剂相似,对甲状腺有致癌作用,对神经和泌尿生殖系统有致畸作用。为进一步研究2-MBI的致畸作用,观察了孕鼠在器官形成期内(7～17天)口服2-MBI后对母体及胎仔的影响 确定剂量:孕鼠分为7组,每组5或6只,在孕7～17天分别口服0、2.5、5、10、20、40、60mg/kg/d的2-MBI。每天记录体重、食量及一般情况,孕20天时处死。记录母体胸腺及子宫重量、胎仔位置、存活情况、黄体数目及存活胎仔的性别、畸形情况。结果:2-MBI使母体体重增加及食量减少的剂量分别为≥
2-mercaptobenzimidazole (2-MBI) is an accelerator and / or antioxidant in the rubber production process. Its structure is similar to that of anti-thyroid drugs and has carcinogenic effects on the thyroid gland and teratogenic effects on the nerve and genitourinary system effect. To further study the teratogenicity of 2-MBI, the effects of oral 2-MBI on the maternal and fetal pregnancy of pregnant rats during organogenesis (7-17 days) were observed. Confirmed Dose: The pregnant rats were divided into 7 groups of 5 Or 6, respectively, 7 to 17 days of pregnancy orally 0,2.5,5,10,20,40,60 mg / kg / d of 2-MBI. Daily record of weight, food intake and general situation, 20 days pregnant were sacrificed. Record maternal thymus and uterine weight, fetal position, survival, number of luteal and surviving fetus sex, deformity. Results: The dose of 2-MBI for maternal weight gain and food intake was ≥