控制粘膜表面免疫应答的机理尚不完全清楚。为了更好地了解这些机理,应当努力发展更有效的方法以刺激保护性粘膜免疫反应。以往曾有报导用可溶性抗原作肠道外免疫,嗣后于粘膜表面用相同抗原免疫时,对此抗原的局部免疫反应降低。同时,业已证明特异性血清抗体可抑制全身免疫反应。本 The mechanism of mucosal surface immune response is not fully understood. In order to better understand these mechanisms, efforts should be made to develop more effective methods to stimulate the protective mucosal immune response. It has been reported in the past that soluble antigens are used for parenteral immunization and subsequent reduction of the local immune response to this antigen upon immunization with the same antigen on the mucosal surface. In the meantime, specific serum antibodies have been shown to inhibit the systemic immune response. this