目的　了解吡柔比星的抗肿瘤活性及毒性反应。方法　以吡柔比星为主联合化疗治疗６２例中晚期恶性肿瘤。结果　完全缓解５ 例、部分缓解３２例，有效率５９．６％ （３７／６２）。毒副反应主要为消化道反应、骨髓抑制、脱发、无肝肾功能损害、无心电图异常。结论　吡柔比星具有抗多种肿瘤活性且毒性作用低，具有较好前景的抗肿瘤药物。 Objective To understand the antitumor activity and toxicity of Pirarubicin. Methods 62 patients with advanced and advanced malignant tumors were treated with pirarubicin plus chemotherapy. Results Complete remission was achieved in 5 patients and partial remission in 32 patients. The effective rate was 59.6% (37/62). The toxicities were mainly gastrointestinal reactions, bone marrow suppression, hair loss, no liver and kidney damage, and no abnormal electrocardiogram. Conclusion Pirarubicin has anti-tumor drugs with good anti-tumor activity and low toxicity.