论文部分内容阅读
合成了一些7-位和5,8-位取代4-喹诺酮-2-羧酸衍生物。经药理筛选,发现化合物(24)(18)对大鼠被动皮肤过敏(PCA)的保护作用分别为98.5%和93.3%。
Some 7-and 5,8-substituted 4-quinolone-2-carboxylic acid derivatives were synthesized. After pharmacological screening, the protective effects of compound (24) (18) on passive cutaneous anaphylaxis (PCA) in rats were 98.5% and 93.3%, respectively.