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目的探讨β-连接素(β-catenin)、生存素(survivin)两种蛋白在子宫内膜异位症(EMs)患者异位内膜和在位内膜的表达、分布及其在EMs发病中的作用与关系。方法应用免疫组织化学法检测31例子宫内膜异位症患者(EMs组)异位内膜和在位内膜及10例非子宫内膜异位症患者(正常对照组)在位内膜中β-连接素、生存素的表达,并检测两者的相关性。结果β-连接素在EMs组囊壁组织、在位内膜中表达的阳性率分别为87.1%(27/31)、83.9%(26/31);生存素在EMs组异位内膜、在位内膜中表达的阳性率分别为90.3%(28/31)、87.1%(27/31);β-连接素、生存素在正常对照组在位内膜表达的阳性率分别为40%(4/10)、30%(3/10)。EMs组异位内膜、在位内膜的β-连接素、生存素表达与正常对照组比较,差异有统计学意义(P<0.05)。EMs组异位内膜、在位内膜中β-连接素与生存素的表达有相关性(r分别为0.850,0.616,P<0.01)。结论子宫内膜β-连接素、生存素的高表达可能在子宫内膜异位症的发病过程中起重要作用。
Objective To investigate the expression and distribution of β-catenin and survivin in eutopic and eutopic endometrium of patients with endometriosis (EMs) and their roles in the pathogenesis of EMs The role and relationship. Methods Immunohistochemistry was used to detect the expression of ectopic and eutopic endometrium in 31 patients with endometriosis (EMs group) and 10 patients with endometriosis (normal control group) β-catenin, survivin expression, and test the correlation between the two. Results The positive rates of β-catenin expression in cytoplasm and eutopic endometrium in EMs group were 87.1% (27/31) and 83.9% (26/31) respectively. Survivin was found in ectopic endometrium of EMs group, The positive rates of endometrial expression in endometriosis were 90.3% (28/31) and 87.1% (27/31), respectively. The positive rates of β-catenin and survivin expression in eutopic endometrium of normal control group were 40% 4/10), 30% (3/10). EMs ectopic endometrium, eutopic endometrial β-catenin, survivin expression compared with the normal control group, the difference was statistically significant (P <0.05). EMs group ectopic endometrium, eutopic endometrium β-catenin and survivin expression (r = 0.850,0.616, P <0.01). Conclusion The high expression of β-catenin and survivin in endometrium may play an important role in the pathogenesis of endometriosis.