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目的:探讨复方氨基酸对肝硬化患者肝功能以及甲胎蛋白(Alpha fetal protein,AFP)、糖类抗原19-9(Carbohydrate antigen19-9,CA199)、癌胚抗原(Cancer embryo antigen,CEA)水平影响。方法:选取我院消化科收治的肝硬化患者98例,根据治疗方法的不同分为两组。对照组予以常规保肝治疗,实验组在对照组的基础上予以复方氨基酸注射液治疗。比较两组患者治疗1周及2周后的肝功能以及AFP、CA199及CEA水平的变化情况。结果:与对照组比较,实验组的临床疗效较高(87.04%Vs 72.22%),(P<0.05)。与对照组比较,治疗一周后实验组ALT水平较低(195.37±13.42 U/L Vs 154.72±13.44 U/L)、AST水平较低(323.41±21.33 U/L Vs 233.55±21.63 U/L),TB水平较低(125.36±4.26 U/L Vs 108.16±6.45 U/L)(P<0.05),治疗两周后,实验组ALT水平较低(124.28±15.84 U/L Vs 78.53±12.55U/L)、AST水平较低(147.15±13.56 U/L Vs 83.42±20.88 U/L),TB水平较低(92.82±9.64 U/L Vs 56.32±7.43)(P<0.05)。结论:复方氨基酸能够影响肝硬化患者肝功能,改善患者的临床症状,提高临床疗效。
Objective: To investigate the effect of compound amino acids on the liver function and the levels of Alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA199) and carcinoembryonic antigen (CEA) . Methods: A total of 98 patients with liver cirrhosis admitted to our hospital were divided into two groups according to the different treatment methods. The control group was given routine hepatoprotective therapy, and the experimental group was given compound amino acid injection on the basis of the control group. The changes of liver function and the levels of AFP, CA199 and CEA in the two groups after one and two weeks of treatment were compared. Results: Compared with the control group, the clinical efficacy of the experimental group was higher (87.04% vs 72.22%) (P <0.05). Compared with the control group, the level of ALT in experimental group was lower (195.37 ± 13.42 U / L Vs 154.72 ± 13.44 U / L) and AST level was lower (323.41 ± 21.33 U / L Vs 233.55 ± 21.63 U / L) (P <0.05). After two weeks of treatment, the level of ALT in the experimental group was lower (124.28 ± 15.84 U / L vs 78.53 ± 12.55 U / L vs 125.36 ± 4.26 U / L vs 108.16 ± 6.45 U / L) ), Lower AST levels (147.15 ± 13.56 U / L Vs 83.42 ± 20.88 U / L) and lower TB levels (92.82 ± 9.64 U / L Vs 56.32 ± 7.43) (P <0.05). Conclusion: The compound amino acids can affect the liver function of patients with cirrhosis, improve the clinical symptoms and improve the clinical curative effect.