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目的探讨重要炎症因子白细胞介素IL-6、IL-10、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、细胞间粘附分子-1(sICAM-1)在冠心病发病过程中的作用及其临床意义。方法采用酶联免疫双抗体夹心法(ELISA)检测各冠心病组及对照组上述炎症因子水平并进行比较分析。结果冠心病组IL-6、IL-10、CRP、TNF-α、sICAM-1水平与对照组相比,差异有统计学意义(P<0.01),不稳定型心绞痛(UAP)组CRP、TNF-α、sICAM-1水平高于稳定型心绞痛(SAP)组(P<0.05),而两者间IL-6、IL-10差异无统计学意义(P>0.05);急性心肌梗死(AMI)组IL-6、IL-10、CRP、TNF-α、sICAM-1水平均高于SAP组及UAP组,差异有统计学意义(P<0.05或P<0.01)。结论 IL-6、IL-10、CRP、TNF-α、sICAM-1参与了冠心病的发生发展,其水平与冠心病病情严重程度密切相关,可能是冠状动脉粥样硬化的标志。
Objective To investigate the effects of interleukin-6, interleukin-10, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (sICAM- The role of the process and its clinical significance. Methods The levels of inflammatory cytokines in each coronary heart disease group and control group were detected by enzyme-linked immunosorbent assay (ELISA) and compared. Results The levels of IL-6, IL-10, CRP, TNF-α and sICAM-1 in coronary heart disease group were significantly higher than those in control group (P <0.01) The levels of sICAM-1 and sICAM-1 in patients with stable angina pectoris (SAP) were significantly higher than those in patients with stable angina pectoris (SAP) (P <0.05) The levels of IL-6, IL-10, CRP, TNF-α and sICAM-1 in SAP group were significantly higher than those in SAP group and UAP group (P <0.05 or P <0.01). Conclusion IL-6, IL-10, CRP, TNF-α and sICAM-1 are involved in the development of coronary heart disease. The level of IL-6, IL-10 and sICAM-1 is closely related to the severity of coronary heart disease and may be a marker of coronary atherosclerosis.