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目的 :观察具有益气养阴、活血解毒作用的肺瘤平二号对中晚期肺癌患者血小板表面糖蛋白表达和血小板激活状态的影响。方法 :采用流式细胞技术检测 30例中晚期肺癌患者服肺瘤平二号前后血小板表面糖蛋白CD4 1/CD4 2a、CD36 /TSP、CD6 2 /CD6 3、CD9、CD31表达的改变 ,并与 50名健康志愿者的检测结果进行对照。结果 :中晚期肺癌患者血小板表面糖蛋白的表达及血小板激活状态明显高于健康志愿者。结论 :服肺瘤平二号可以部分减少中晚期肺癌患者血小板表面糖蛋白的表达和血小板激活状态。
Objective : To observe the effect of Tuofeipinghao on the expression of platelet surface glycoprotein and platelet activation in patients with advanced lung cancer. METHODS: Flow cytometry was used to detect the changes of platelet surface glycoproteins CD4 1/CD4 2a, CD36/TSP, CD6 2 /CD6 3, CD9, and CD31 expression in 30 lung cancer patients with intermediate-late lung cancer. The test results of 50 healthy volunteers were compared. Results: The platelet surface glycoprotein expression and platelet activation in patients with advanced lung cancer were significantly higher than those in healthy volunteers. Conclusion :Fuzhen Pingyao II can partially reduce platelet surface glycoprotein expression and platelet activation in patients with advanced lung cancer.