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卡马西平除抗惊厥作用外,还可引起许多代谢的改变,可使血清高密度脂蛋白胆固醇(HDL—C)增高,但对血清胆固醇(CH)、低密度脂蛋白胆固醇(LDL—C)和甘油三酯(TG)的影响报导不一,尚缺少前瞻性研究。作者随访观察了36例(男21例,女15例,平均年龄32.1岁)特发性癫病病人卡马西平治疗期间的血脂变化。所有病人在治疗前均没用过抗痫药物,给予卡马西平治疗后,大多数病例达到有效血浓度时癫痫得到较好控制,一年内得到完全控制。2月后平均药物剂量是522±87mg/日,血浓度为27.8±6.0μmol/L,12个月后则分别为517±87mg/日和26.6±5.2μmol/L。
In addition to anticonvulsant effects, carbamazepine can cause many metabolic changes, which can increase serum high density lipoprotein cholesterol (HDL-C), but not serum cholesterol (CH), low density lipoprotein cholesterol (LDL-C) And triglyceride (TG) reported different effects, but the lack of prospective studies. The follow-up observation of 36 patients (21 males and 15 females, mean age 32.1 years) patients with idiopathic epilepsy during carbamazepine treatment of lipid changes. All patients before treatment did not use anti-epileptic drugs, given carbamazepine treatment, the majority of cases to achieve effective blood concentration when epilepsy is better controlled within one year of complete control. After 2 months, the mean dose was 522 ± 87 mg / day with a blood concentration of 27.8 ± 6.0 μmol / L and 517 ± 87 mg / day and 26.6 ± 5.2 μmol / L after 12 months respectively.