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目的:探讨多巴胺与多巴酚丁胺佐治西宁地区重度新生儿缺氧缺血性脑病(HIE)的疗效。进一步提高HIE的治疗效果。方法:对我科确诊的86例重度HIE患儿随机分成两组,两组均采用综合治疗,观察组加用多巴胺与多巴酚丁胺,用微量输液泵输入,与对照组比较其治疗前后症状、体征及心电图、肾功恢复时间。结果:观察组在神智恢复时间、原始反射恢复时间、肌张力恢复时间、心、肾功恢复时间方面均明显优于对照组(P<0.01)。结论:多巴胺与多巴酚丁胺佐治重度HIE,可增加心及脑灌流量,改善微循环,增强心肌收缩力,改善心功能,使动脉血压升高。并可扩张肾血管,改善肾灌注促进肾功能恢复。这两种药药源广、价廉,在基层推广方便,可作为佐治HIE的主要药物之一。
Objective: To investigate the therapeutic effect of dopamine and dobutamine in the treatment of severe neonatal hypoxic-ischemic encephalopathy (HIE) in Xining area. Further improve the therapeutic effect of HIE. Methods: A total of 86 severe HIE children diagnosed in our department were randomly divided into two groups. The two groups were treated with combination therapy. Dopamine and dobutamine were used in the observation group. The patients were injected with micro infusion pump. Compared with the control group, Symptoms, signs and ECG, kidney function recovery time. Results: The observation group was significantly better than the control group (P <0.01) in terms of the recovery time, initial reflection recovery time, muscle tone recovery time, heart and kidney recovery time. Conclusion: Dopamine and dobutamine adjuvant severe HIE can increase cardiac and cerebral perfusion, improve microcirculation, increase myocardial contractility, improve cardiac function, and increase arterial blood pressure. And can expand renal blood vessels, improve renal perfusion and promote renal function recovery. These two kinds of medicine source wide, inexpensive, easy to promote at the grassroots level, as George HIE one of the main drugs.